Journal of Clinical Investigation has published that the molecular mechanism is the reason for cannabis to help treat inflammatory bowel disease.
Inflammatory bowel symptoms disease affects the gastrointestinal tract, similarly as ulcerative colitis and Crohn’s disease.
IBD will often lead a person having symptoms of weakness, like rectal bleeding, diarrhea, fatigue, and abdominal pain.
In the older studies and anecdotal, it is seen that people using cannabis maintain and experience relief from the condition. People who use cannabis say that this drug helps them to manage successfully joint pain, diarrhea, abdominal pain, cramping, weight loss, nausea, and poor appetite.
After cannabis is getting legal in many countries, the researchers are also finding it easy it easy to find cannabis and are trying to do more researches these days on cannabis, and first-time researchers have come up with a biological mechanism that makes it clear why cannabis relieves IBD.
What is the biological mechanism?
The research was started on already known inflammation process when a pathogen infects the body. The immune system sends neutrophils (a type of white blood cell), to fight against any foreign microorganisms like bacteria and virus, and this is called neutrophil influx. But when the immune cells don’t react in the right way, epithelium gets destroyed, which lines the inner intestine and protects the layer. Special molecules are dispatched across the epithelium to stop the inflammation when any overreaction occurs of the immune response.
Researchers found that for the second process to take place endogenous cannabinoids are required, and it is a naturally produced cannabinoids inside our body and has the same effect as cannabis cannabinoids do.
The experiment done on human and mice cells found that when there’s a lack of endocannabinoids or there are an insufficient number of endocannabinoids, a body won’t be to control inflammation anymore, and then protective intestinal layer gets attacked by neutrophils.
The scientist now thinks that cannabinoids can make up for the natural cannabinoids, and they can fulfill the place of the lacking or insufficient endocannabinoids.
You can get more information about medical marijuana on clicking over the link licensed producers Canada.
